雙鏈RNA腺苷酸脫氨基酶抗體（C端）（）

英文名稱： Anti-ADAR1 （C-terminus）                                  濃度： 1mg/1ml 

抗體來源：Rabbit

克隆類型：polyclonal          

 交叉反應：    Human, Mouse, Rat,   

產品類型: 一抗  

性    狀:Lyophilized or Liquid 

保存條件： Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C. 

產品介紹 ：ADAR1 converts adenosine to inosine in dsRNA, which destabilizes the dsRNA helix. This activity is important for various functions like site-specific RNA editing of transcripts of the glutamate receptors and modifying viral RNA genomes （which may be responsible for hypermutation of certain negative-stranded viruses, e.g., measles virus）. ADAR1 also binds to short interfering RNAs （siRNA） without editing them and suppresses siRNA-mediated RNA interference. This protein is ubiquitously expressed, with the highest levels being found in brain and lung.

Function : Converts multiple adenosines to inosines and creates I/U mismatched base pairs in double-helical RNA substrates without apparent sequence specificity. Has been found to modify more frequently adenosines in AU-rich regions, probably due to the relative ease of melting A/U base pairs as compared to G/C pairs. Functions to modify viral RNA genomes and may be responsible for hypermutation of certain negative-stranded viruses. Edits the messenger RNAs for glutamate receptor （GLUR） subunits by site-selective adenosine deamination. Produces low-level editing at the GLUR-B Q/R site, but edits efficiently at the R/G site and HOTSPOT1. Binds to short interfering RNAs （siRNA） without editing them and suppresses siRNA-mediated RNA interference. Binds to ILF3/NF90 and up-regulates ILF3-mediated gene expression.
Subunit : Homodimer. Isoform 1 interacts with ILF2/NF45 and ILF3/NF90.
Subcellular Location : Cytoplasm. Nucleus, nucleolus. Isoform 1: Cytoplasm. Note=Found predominantly in cytoplasm but appears to shuttle between the cytoplasm and nucleus. Isoform 5: Nucleus, nucleolus.
Tissue Specificity : Ubiquitously expressed, highest levels were found in brain and lung.
Post-translational modifications : Sumoylation reduces RNA-editing activity.
DISEASE : Defects in ADAR are a cause of dyschromatosis symmetrical hereditaria （DSH） [MIM:127400]; also known as reticulate acropigmentation of Dohi. DSH is a pigmentary genodermatosis of autosomal dominant inheritance characterized by a mixture of hyperpigmented and hypopigmented macules distributed on the dorsal parts of the hands and feet.
Similarity : Contains 1 A to I editase domain.
Contains 2 DRADA repeats. 
Contains 3 DRBM （double-stranded RNA-binding） domains.

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