Description
Biochem/physiol Actions One of a group of fungal metabolites that interfere with a wide variety of cellular movements. Useful tool for characterizing some of the polymerization properties of actin,1 and in studies on cytokinesis.2 Probe for the two hexose-transport systems in rat L6 myoblasts.3
Cell permeable fungal toxin that disrupts contractile microfilaments by inhibiting actin polymerization. This, in turn, induces DNA fragmentation, inhibits cell division, and disrupts many cell processes. Inhibits glucose transport.
Properties
assay ≥98% （HPLC）
form powder
color white
solubility ethanol: 20 mg/mL
DMSO: soluble
storage temp. −20°C
Safety
Personal Protective Equipment Eyeshields, Faceshields, full-face particle respirator type N100 （US）, Gloves, respirator cartridge type N100 （US）, type P1 （EN143） respirator filter, type P3 （EN 143） respirator cartridges
Hazard Codes T+
Risk Statements 26/27/28-63
Safety Statements 28-36/37-45
RIDADR UN1544 6.1/PG 2
WGK Germany 3
RTECS RO0205000
References
Cited Reference 1. E.D.Korn Physiol. Rev. 62, 672, （1982）
2. S. Eperon J. Protozool. 33, 43, （1986）
3. S.R.Chen Biochem. J. 251, 3, （1988）
reference Theodoropoulos, P.A., et al., Cytochalasin B may shorten actin filaments by a mechanism independent of barbed end capping. Biochem. Pharmacol. 47, 1875-1881, （1994） Abstract
Kilber, M.A., et al., Cytochalasin B induces cellular DNA fragmentation. FASEB J. 4, 3021-3027, （1990） Abstract
Cimini, D., et al., Simultaneous inhibition of contractile ring and central spindle formation in mammalian cells treated with cytochalasin B. Chromosoma 107, 479-485, （1998） Abstract
Soreng, K.M., et al., A role for microfilaments but not microtubules in processing soluble antigens. Cell. Immunol. 166, 25-34, （1995） Abstract
Toyohara, A., and Inaba, K., Transport of phagosomes in mouse peritoneal macrophages. J. Cell Sci. 94 （ Pt 1）, 143-153, （1989） Abstract
Forscher, P., and Smith, S.J., Actions of cytochalasins on the organization of actin filaments and microtubules in a neuronal growth cone. J. Cell Biol. 107, 1505-1516, （1988） Abstract
Chien, C.B., et al., Navigational errors made by growth cones without filopodia in the embryonic Xenopus brain. Neuron 11, 237-251, （1993） Abstract
Walmsley, A.R., et al., Sugar transporters from bacteria, parasites and mammals: structure-activity relationships. Trends Biochem. Sci. 23, 476-481, （1998） Abstract
Pedro Goncalves, et al., Lack of a significant effect of cannabinoids upon the uptake of 2-deoxy-D-glucose by Caco-2 cells. Pharmacology 82, 30-37, （2008） Abstract
Bylund, J., et al., Cytochalasin B triggers a novel pertussis toxin sensitive pathway in TNF-alpha primed neutrophils. BMC Cell Biol. 5, 21, （2004） Abstract
Diaz-Ricart M., et al., Inhibition of cytoskeletal assembly by cytochalasin B prevents signaling through tyrosine phosphorylation and secretion triggered by collagen but not by thrombin. Am. J. Pathol. 160, 329-337, （2002） Abstract
Merck Merck 13,2819
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