磷酸化水通道蛋白2抗體（）

英文名稱：  Anti-phospho-AQP2（Ser264）                           濃度： 1mg/1ml 

抗體來源：Rabbit

克隆類型：polyclonal          

 交叉反應(yīng)：Human, Mouse, Rat, Chicken, Dog, Pig, Cow, Sheep, 

產(chǎn)品類型: 一抗  

性    狀:Lyophilized or Liquid 

保存條件： Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C. 

產(chǎn)品介紹 ：This gene encodes a water channel protein located in the kidney collecting tubule. It belongs to the MIP/aquaporin family, some members of which are clustered together on chromosome 12q13. Mutations in this gene have been linked to autosomal dominant, and recessive forms of nephrogenic diabetes insipidus. Belongs to the MIP/aquaporin （TC 1.A.8） family.

Function : Forms a water-specific channel that provides the plasma membranes of renal collecting duct with high permeability to water, thereby permitting water to move in the direction of an osmotic gradient.
Subcellular Location : Apical cell membrane; Multi-pass membrane protein. Cytoplasmic vesicle membrane; Multi-pass membrane protein. Note=Shuttles from vesicles to the apical membrane.
Tissue Specificity : Expressed in renal collecting tubules.
Post-translational modifications : Ser-256 phosphorylation is necessary and sufficient for expression at the apical membrane. Endocytosis is not phosphorylation-dependent.
DISEASE : Defects in AQP2 are the cause of diabetes insipidus nephrogenic autosomal （ANDI） [MIM:125800]; also known as diabetes insipidus nephrogenic type 2. ANDI is caused by the inability of the renal collecting ducts to absorb water in response to arginine vasopressin. It is characterized by excessive water drinking （polydypsia）, excessive urine excretion （polyuria）, persistent hypotonic urine, and hypokalemia. Inheritance can be autosomal dominant or recessive.
Similarity : Belongs to the MIP/aquaporin （TC 1.A.8） family.
水通道蛋白-2特異地存在于腎臟集合管，受血管加壓素調(diào)節(jié)。有研究證明，AQP2（水通道蛋白-2）在糖尿病腎臟集合管表達(dá)增強(qiáng). 在1型糖尿病動物模型的水轉(zhuǎn)運(yùn)中尤其有意義。研究認(rèn)為：AQP-2 奠定了糖尿病大鼠腎臟對水重吸收的基礎(chǔ)，而且發(fā)現(xiàn)1型糖尿病病人的 AQP-2隨血糖控制而減少。

公司對外提供生物技術(shù)外包服務(wù)：卡邁舒（上海）生物科技專業(yè)經(jīng)營一抗二抗,單克隆多克隆抗體,指標(biāo)上千萬種,質(zhì)量好,價格實惠,售后問題負(fù)責(zé)到底,

單克隆抗體定制服務(wù)，多克隆抗體定制，單克隆抗體純化   ，多克隆抗體純化  ，

抗體HRP標(biāo)記  ，抗原HRP標(biāo)記  ，抗體膠體金標(biāo)記，抗體FITC標(biāo)記，小鼠單抗Ig類/亞類鑒定，獸用細(xì)胞水平檢測（比如干擾素等），多肽半抗原的偶聯(lián)，

親和層析柱制備 （客戶提供抗原抗體）