載脂蛋白L1抗體（）

英文名稱： Anti-APOL1/Apolipoprotein L                                   濃度： 1mg/1ml 

抗體來源：Rabbit

克隆類型：polyclonal          

 交叉反應(yīng)： Human,    

產(chǎn)品類型: 一抗  

性    狀:   Lyophilized or Liquid 

保存條件： Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C. 

產(chǎn)品介紹 ：Apolipoproteins are protein components of plasma lipoproteins （1）. The apolipoprotein L gene family encodes six highly homologous proteins designated apoL-I to -VI, which are associated with large high density type lipoproteins （HDL） （2,3）. The human apoL family maps to chromosome 22q12.1-13.1 within a 127,000-bp region （4）. ApoL has been characterized as a pancreas specific, 383-amino acid protein that contains a 12-amino acid secretory signal peptide （4）. The apoL genes have TATA-less promoters and contain putative sterol regulatory elements, suggesting that transcription of these genes may be coordinated with that of the low density lipoprotein receptor and genes in pathways involving the synthesis of triglycerides and cholesterol （3）. ApoL homologs can undergo 10 fold changes in expression during atherosclerotic changes in vascular endothelial cells, which includes the inflammatory reaction of atherosclerotic lesions （5）.

Function : May play a role in lipid exchange and transport throughout the body. May participate in reverse cholesterol transport from peripheral cells to the liver.
Subunit : In plasma, interacts with APOA1 and mainly associated with large high density lipoprotein particles. 
Subcellular Location : Secreted.
Tissue Specificity : Plasma. Found on APOA-I-containing high density lipoprotein （HDL3）. Expressed in pancreas, lung, prostate, liver, placenta and spleen.
Post-translational modifications : Phosphorylation sites are present in the extracelllular medium.
DISEASE : Defects in APOL1 are the cause of focal segmental glomerulosclerosis type 4 （FSGS4） [MIM:612551]. It is a renal pathology defined by the presence of segmental sclerosis in glomeruli and resulting in proteinuria, reduced glomerular filtration rate and edema. Renal insufficiency often progresses to end-stage renal disease, a highly morbid state requiring either dialysis therapy or kidney transplantation.
Similarity : Belongs to the apolipoprotein L family.
Database links : UniProtKB/Swiss-Prot: O14791.5

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