DNA修復酶相互作用蛋白抗體（）

英文名稱： Anti-APLF                                  濃度： 1mg/1ml 

抗體來源：Rabbit

克隆類型：polyclonal          

 交叉反應：Human, Mouse, Rat, 

產(chǎn)品類型: 一抗  

性    狀:   Lyophilized or Liquid 

保存條件： Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C. 

產(chǎn)品介紹 ：APLF is a 511 amino acid protein that contains one FHA doman and two C2H2type zinc fingers. Localized to both the nucleus and the cytoplasm, APLF interacts with XRCC1, XRCC4 and Ku-86 and, via these interactions, is involved in single-strand and double-strand DNA break repair. APLF is subject to post-translational phosphorylation in response to DNA breaks. The gene encoding APLF maps to human chromosome 2, which houses over 1,400 genes and comprises nearly 8% of the human genome. Harlequin icthyosis, a rare and morbid skin deformity, is associated with mutations in the ABCA12 gene, while the lipid metabolic disorder sitosterolemia is associated with defects in the ABCG5 and ABCG8 genes. Additionally, an extremely rare recessive genetic disorder, is caused by mutations in the ALMS1 gene, which maps to chromosome 2.

Function : Nuclease involved in single-strand and double-strand DNA break repair. Recruited to sites of DNA damage through interaction with poly（ADP-ribose）, a polymeric post-translational modification synthesized transiently at sites of chromosomal damage to accelerate DNA strand break repair reactions. Displays apurinic-apyrimidinic （AP） endonuclease and 3'-5' exonuclease activities in vitro. Also able to introduce nicks at hydroxyuracil and other types of pyrimidine base damage.
Subunit : Interacts with LIG4, PARP1, XRCC1, XRCC4 and XRCC5. 
Subcellular Location : Nucleus. Cytoplasm; cytosol. Localizes to DNA damage sites. Accumulates at single-strand breaks and double-strand breaks via the PBZ-type zinc fingers.
Post-translational modifications : Poly-ADP-ribosylated. In addition to binding non covalently poly（ADP-ribose） via its PBZ-type zinc fingers, the protein is also covalently poly-ADP-ribosylated by PARP1.
Phosphorylated in an ATM-dependent manner upon double-strand DNA break.
Similarity : Belongs to the APLF family.
Contains 1 FHA-like domain.
Contains 2 PBZ-type zinc fingers.
Database links : UniProtKB/Swiss-Prot: Q8IW19.1

公司對外提供生物技術(shù)外包服務：卡邁舒（上海）生物科技專業(yè)經(jīng)營一抗二抗,單克隆多克隆抗體,指標上千萬種,質(zhì)量好,價格實惠,售后問題負責到底,

單克隆抗體定制服務，多克隆抗體定制，單克隆抗體純化   ，多克隆抗體純化  ，

抗體HRP標記  ，抗原HRP標記  ，抗體膠體金標記，抗體FITC標記，小鼠單抗Ig類/亞類鑒定，獸用細胞水平檢測（比如干擾素等），多肽半抗原的偶聯(lián)，

親和層析柱制備 （客戶提供抗原抗體）